Im Folgenden eine Liste von Krebsarten, bei denen Imatinib in klinischen Studien in den USA getestet wird (ohne Anspruch auf Vollständigkeit):
- Chronic Myeloid Leukemia
- Breast Cancer
- GIST; Sarcoma
- Thyroid Cancer
- Adenoid Cystic Carcinoma of the Head and Neck
- Hypereosinophilic Syndrome
- Medullary Thyroid Carcinoma
- Hypereosinophilic Syndrome; Systemic Mastocytosis; Chronic Myelomonocytic Leukemia; Dermatofibrosarcoma
- Thymic Carcinoma
- Chordoma
- Glioblastoma
- Pancreatic Cancer
- Adult Anaplastic Astrocytoma; Adult Anaplastic Oligodendroglioma; Adult Brain Tumor; Adult Glioblastoma; Mixed Gliomas
- Unspecified Adult Solid Tumor, Protocol Specific
- Recurrent Adult Brain Tumor
- Adult Acute Erythroid Leukemia; Adult Acute Monoblastic and Acute Monocytic Leukemia; Adult Acute Myeloid Leukemia
- Stage III Melanoma; Stage IV Melanoma; Recurrent Melanoma; Unspecified Adult Solid Tumor, Protocol Specific
- Stage III Renal Cell Cancer; Stage IV Renal Cell Cancer; Renal Clear Cell Carcinoma; Recurrent Renal Cell Cancer
- Male Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer; Stage IV Breast Cancer; Recurrent Breast Cancer
- Adult Acute Lymphoblastic Leukemia in Remission
- Non-Small Cell Lung Cancer; Lung Cancer; Recurrent Lung Cancer; Metastatic Lung Cancer
- Hypereosinophilic Syndrome; Chronic Eosinophilic Leukemia (CEL); Myeloproliferative Disorders
- Adult Acute Erythroid Leukemia; Adult Acute Monoblastic and Acute Monocytic Leukemia; Adult Acute Myeloid Leukemia; ...
- Chronic Idiopathic Myelofibrosis; Polycythemia Vera; Essential Thrombocythemia
- Desmoid Tumor
- Epidemic Kaposi's Sarcoma; Recurrent Kaposi's Sarcoma
- Stage III Merkel Cell Carcinoma; Recurrent Merkel Cell Carcinoma; Stage II Merkel Cell Carcinoma
- Recurrent Adult Soft Tissue Sarcoma; Stage III Adult Soft Tissue Sarcoma; Stage IV Adult Soft Tissue Sarcoma; Adult Fibrosarcoma; ...
- Adult Fibrosarcoma; Recurrent Adult Soft Tissue Sarcoma; Stage III Adult Soft Tissue Sarcoma; Adult Malignant Fibrous Histiocytoma; ...
- Gastric Adenocarcinoma
- Prostate Cancer
- Colon Cancer; Colorectal Cancer
- Dermatofibrosarcoma Protuberans; Newly Diagnosed or Recurrent
Quelle:
http://www.clinicaltrials.gov/ct/sea...&submit=Search
Dabei darf man nicht vergessen, dass imatinib nur ein Vertreter aus einer ganzen Wirkstoffklasse (genannt Tyrosinkinase-Hemmer) ist. Und es werden monatlich mehr...schon beeindruckend!
Bleibt zu hoffen, dass diese Wirkstoffe bei anderen Tumorarten den gleichen Durchbruch bringen wie bei CML und Gist...